Program
The symposium will highlight cutting-edge developments in top-down proteomics, from sample preparation and separation technologies to native MS, bioinformatics, and the analysis of proteoforms and PTMs. Applications in biomedical research, therapeutic proteins, and proteoform function will also be featured!
Explore in-depth insights into top-down proteomics—join our expert-led short courses!
Explore topics and confirmed speakers below:
Biomedical Applications
Ge, Ying:
"Cardiac troponin proteoforms" (preliminary title)
Affiliation: University of Wisconsin-Madison, Madison; USA
Glocker, Michael:
"Mass spectrometric ITEM-FOUR analysis reveals coding single nucleotide polymorphisms in human cardiac troponin T that evade detection by sandwich ELISAs which use monoclonal antibodies M7 and M11.7 from the Elecsys Troponin T® assay"
Affiliation: University of Rostock, Rostock; Germany
Lageveen-Kammeijer, Guinivere:
"Dissecting the Proteoform Landscape of Prostate-Specific Antigen: Intact, Bottom-Up, and Glycomic Perspectives"
Affiliation: Groningen University, Groningen; Netherlands
Biopharmaceutical & Therapeutic Proteins
Chamot-Rooke, Julia:
"Monitoring mAb proteoforms blood plasma" (preliminary title)
Affiliation: Institut Pasteur, Paris; France
Heck, Albert:
"Analysis of Antibody-Drug Conjugate by Top-Down Mass Spectrometry" (preliminary title)
Affiliation: Utrecht University, Utrecht, Netherlands
Wuhrer, Manfred:
"Functional and structural characterization of antibodies by native-mode affinity separation-, middle-up, and top-down mass spectrometry"
Affiliation: Leiden University, Leiden; Netherlands
Tsybin, Yury:
"Top-Down and Middle-Down Mass Spectrometry of Antibodies" (preliminary title)
Affiliation: Spectroswiss, Lausanne; Switzerland
Databases & Bioinformatics
Jeong, Kyowon:
"Computational methods in top-down proteomics to address challenges in proteoform analysis"
Affiliation: Eberhard Karls University, Tübingen; Germany
Agar, Jeffrey:
"Replacing “or” logic and mass accuracy with "and/or" logic and mass resolving power, as the basis for peak assignment in top-down mass spectrometry data"
Affiliation: Northeastern University, Bouvé College of Health Sciences, Boston; USA
David Tabb:
"Algorithms for proteoform identification via top-down mass spectrometry" (preliminary title)
Affiliation: Groningen University, Groningen; Netherlands
Vizcaino, Juan Antonio:
"The PRIDE database at 20 years" (preliminary title)
Affiliation: EMBL-EBI, Hinxton; Great Britain
Native MS & Protein Complexes
Loo, Joseph A:
"Revealing Functional Proteoforms by Native Top-Down Proteomics"
Affiliation: UCLA, Los Angeles; USA
Sharon, Michal:
"Uncovering the unique properties of circulating proteasomes: A mass spectrometry perspective"
Affiliation: Weizmann Institute of Science, Rehovot; Israel
Zhou, Mowei:
"Filling the Structural Knowledge Gap in Protein Design via Native Mass Spectrometry"
Affiliation: Zhejiang University, Hangzhou; China
Uetrecht, Charlotte:
"Flying viruses – mass spectrometry meets X-rays"
Affiliation: University of Lübeck, CSSB Centre for Structural Systems Biology, Deutsches Elektronen Synchrotron DESY, Lübeck & Hamburg; Germany
New Tools for Proteoform Analysis
Jensen, Ole Nørregaard:
"Top-down sequencing of intact, modified proteins by timsTOF technology with new multi-modal fragmentation capabilities"
Affiliation: University of Southern Denmark (SDU), Odense; Denmark
Papanastasiou, Dimitris:
"Advances in hardware design and function of the new timsOmni MS platform"
Affiliation: Fasmatech Science and Technology, Athens; Greece
Paša-Tolić, Ljiljana:
"Spatial top-down proteomics" (preliminary title)
Affiliation: Pacific Northwest National Laboratory (PNNL), Richland; USA
Schlüter, Hartmut:
"Nanosecond & Picosecond Infrared laser systems for getting closer to the original proteoform composition in tissues"
Affiliation: Hamburg University, Hamburg; Germany
Proteoform Functions
Kelleher, Neil:
"Digitizing Proteoform Biology with Single Molecule & Single Cell Mass Spectrometry"
Affiliation: Northwestern University, Chicago; USA
Smith, Lloyd:
"New frontiers in proteomics - proteoforms, proteoform families, and the human proteoform project"
Affiliation: University of Wisconsin-Madison, Madison; USA
Sample Preparation & Separation Technologies
Liang, Yu:
"Novel bridged hybrid monolithic columns combined with mass spectrometry for top-down proteomic analysis"
Affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian; China
Takemori, Nobuaki:
"Gel-Based Proteoform separation for Top-Down Proteomics" (preliminary title)
Affiliation: Ehime University School of Medicine, Matsuyama; Japan
Tholey, Andreas:
"Impact of sample preparation methods on proteoform identification" (preliminary title)
Affiliation:Christian-Albrechts-University, Kiel; Germany